This site is intended for patients and caregivers.
For healthcare professionals
This site is intended for patients and caregivers.
For healthcare professionals
Atypical-HUS shares signs and symptoms with other disorders, including thrombotic microangiopathy (TMA). Getting to the right diagnosis can be difficult. These are some of the ways in which atypical-HUS can affect the body’s major organs and systems.
Patients may experience a few, several, or many symptoms, and they may appear in a gradual manner or suddenly and without warning. Some symptoms include:
No two people experience atypical-HUS in exactly the same way, which can sometimes delay diagnosis
TMA occurs in many different disorders, with different underlying causes. In atypical-HUS, uncontrolled complement activity is what causes TMA and its potentially life-threatening effects.
Symptoms may include tiny purple, red, or brown spots on the skin, bruising, prolonged bleeding, blood in urine or stool, other abnormal bleeding, and headaches
Blood flow to vital organs is reduced, which can cause fatigue, difficulty breathing, dark urine, back pain, jaundice or paleness, blood clots, stroke, and heart attack
Filtering an excess of damaged and destroyed cells overwhelms the kidneys, which may cause listlessness, confusion, weight loss, nausea, vomiting, weight gain, swelling of body parts, abnormally low urine output, and brain complications
1. In atypical-HUS, uncontrolled complement activity causes blood platelets to become overactive.
Learn more about atypical-HUS, its causes and symptoms, and resources that
are available to help those living with the disease and their
caregivers.
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