Identification of TMA
Thrombocytopenia
Platelet count <150 × 109/L
or >25% decrease from baseline
AND
Microangiopathic hemolysis
Schistocytes and/or
Elevated LDH and/or
Decreased haptoglobin and/or
Decreased hemoglobin
PLUS 1 or more of the following symptoms:
Common Symptoms
- Confusion
- Seizures
- Stroke
- Other cerebral abnormalities
- Elevated creatinine level
- Decreased eGFR
- Elevated blood pressure
- Abnormal urinalysis results
- Diarrhea ± blood
- Nausea/vomiting
- Abdominal pain
- Gastroenteritis/pancreatitis
Other Symptoms
- Myocardial infarction
- Hypertension
- Arterial stenosis
- Peripheral gangrene
- Dyspnea
- Pulmonary hemorrhage
- Pulmonary edema
- Pain and blurred vision
- Retinal vessel occlusion
- Ocular hemorrhage