Atypical-HUS is a difficult diagnosis to navigate, but the right information can help you and your patients

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aHUS OVERVIEW DIAGNOSING aHUS

Complement amplifying triggers can unmask atypical-HUS1,2

Atypical hemolytic uremic syndrome (atypical-HUS) is a rare, chronic disease characterized by uncontrolled activation of the complement system causing thrombotic microangiopathy (TMA) and organ damage.1,5 A number of triggers can amplify complement system activation and unmask underlying atypical-HUS.1,2

70% of patients (191/273) with atypical-HUS presented their first clinical manifestation while experiencing a trigger.3 Some examples of triggers include pregnancy or postpartum experiences, autoimmune disease, malignant hypertension, and organ transplantation. Understanding how patients may present with triggers can help to appropriately diagnose atypical-HUS as quickly as possible.4

LEARN ABOUT aHUS TRIGGERS
Pregnancy/Postpartum
Malignant Hypertension
Organ Transplantation
Autoimmune Diseases
Glomerulonephritis
Malignancy
Infections
CertainMedications
Surgery/Trauma

These are some triggers seen in atypical-HUS patients. Additional triggers may exist.

Atypical-HUS is a disease associated with chronic risk of complement-mediated TMA and life-threatening consequences4,5

aHUS PATHOGENESIS

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