What are the risks of aHUS?

People with aHUS are at constant risk of sudden, catastrophic, and life-threatening symptoms and complications. As the disease continues to damage small blood vessels, vital organs can fail to work, either suddenly or over time.1-6

Here are some key facts about aHUS:

  • aHUS damages the kidneys. The kidneys’ job is to clean toxins from the blood and eliminate them through the urine. Many people will need long-term dialysis or kidney transplant if their kidneys stop working1,7
  • Almost half (46%) of patients experience pulmonary symptoms8
  • Extremely high blood pressure and edema (swelling) are other complications9,10
  • Almost half (up to 49%) of patients experience neurological (brain and nervous system) symptoms9
  • About 4 out of 10 patients (up to 44%) of patients have cardiovascular (heart and circulation) problems9
  • Almost half (up to 51%) have diarrhea and other problems linked to the digestive system9

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1. Laurence J, et al. Clin Adv Hematol Oncol. 2016;14 Suppl 11(11):2-15. 2. Legendre CM, et al. N Engl J Med. 2013;368(23):2169-2181. 3. Sellier-Leclerc A-L, et al. J Am Soc Nephrol. 2007;18(8):2392-2400. 4. Noris M, et al. Nat Rev Nephrol. 2012;8(11):622-633. 5. Noris M, et al. Clin J Am Soc Nephrol. 2010;5(10):1844-1859. 6. Caprioli J, et al. Blood. 2006;108(4):1267-1279. 7. Cofiell R, et al. Blood. 2015;125(21):3253-3262. 8. Muus P, Loirat C, Licht C, et al. Presented at: 18th Congress of the European Hematology Association. June 13-16, 2013; Stockholm, Sweden. Abstract B1774. 9. Jamme M, et al. PLoS One. 2017;12(5):e0177894. 10. Stahl AL, et al. Blood. 2008;111(11):5307- 5315.