Learn about atypical hemolytic uremic syndrome (aHUS)
atypical hemolytic uremic syndrome (aHUS) is a life threatening disease with devastating consequences1,2
It may be scary to find out that you or your loved one may have aHUS. Although aHUS is a life-threatening disease, learning about your disease is important. The more you know, the better you can manage it.1
Here are some key facts about aHUS:
- aHUS is caused by genetic problems in the complement system, which is a part of the body's immune system1
- aHUS is important to diagnose accurately because it has signs and symptoms that are similar to those of other diseases. Differentiating aHUS from other similar diseases as soon as possible is very important1,3
- Plasma exchange/infusion has been used to manage aHUS symptoms, but plasma therapy has not been studied in well-controlled trials in aHUS4
Learn more about aHUS
- What Is aHUS?
aHUS is a disease of uncontrolled complement activation that affects as many adults as it does children.5,6
- How Do You Get aHUS?
aHUS is caused by a change, or mutation, in a person's genes. However, the absence of an identified genetic mutation does not rule out aHUS.1,3,7-9
- How is aHUS Diagnosed?
It's important to diagnose aHUS accurately because it has signs and symptoms similar to those of other diseases.1,3
- What Are the Risks of aHUS?
People with aHUS have an ongoing risk of sudden, life-threatening complications.1,2
- What Are the Management Options for aHUS?
Historical management options for aHUS have not been demonstrated in prospective clinical trials in aHUS to be either safe or effective.1,4
- Discuss aHUS with Your Doctor
Here you will find guides to help you and your doctor work together on managing aHUS, whether you're new to the disease or currently being treated for aHUS.
1. Laurence J, et al. Clin Adv Hematol Oncol. 2016;14 Suppl 11(11):2-15. 2. Legendre CM, et al. N Engl J Med. 2013;368(23):2169-2181. 3. Azoulay E, et al. Chest. 2017;152(2):424-434. 4. Schwartz J, et al. J Clin Apher. 2016;31(3):149-338. 5. Noris M, et al. Clin J Am Soc Nephrol. 2010;5(10):1844-1859. 6. Caprioli J, et al. Blood. 2006;108(4):1267-1279. 7. Noris M, et al. Nat Rev Nephrol. 2012;8(11):622-633. 8. Campistol JM, et al. Nefrologia. 2015;35(5):421-447. 9. Jokiranta TS. Blood. 2017;129(21):2847-2856.