• Chapter 1: Overview of Disease and Diagnosis
    Provides an overview of atypical Hemolytic Uremic Syndrome and its chronic, progressive, devastating and life-threatening nature

  • Chapter 2: The Role of Complement in aHUS
    Discusses the pathophysiology of aHUS and the underlying chronic complement-mediated Thrombotic Microangiopathy (TMA) that causes chronic and progressive damage in aHUS

  • Chapter 3: aHUS: Early Diagnosis is Critical to Improve Patient Outcomes
    TMAs often share the same clinical presentations but differ in the underlying cause, high clinical suspicion of aHUS is required in all patients presenting with TMA

  • Chapter 4: aHUS is a clinical diagnosis supported by appropriate exclusion of other TMAs
    Illustrates the diagnostic pathway that differentiates aHUS from other TMAs diseases

  • Chapter 5: Summary
    aHUS causes sudden and progressive damage. It's a chronic, progressive, life-threatening condition, and has systemic impact

  • Bruce E. Berger, M.D.

    Bruce Berger MD is Medical Director of the Renal Ward at the University Hospitals of Cleveland and an Associate Professor of Medicine at the Case Western Reserve University in Cleveland, OH. He is Board Certified in Internal Medicine and Nephrology, has been widely published, and lectures regularly on conditions and treatments related to renal disorders. Dr. Berger continues to serve as a Principal Investigator in clinical trials for treatments for polycystic and other kidney diseases.

    Dr. Berger is a member of the American Society of Nephrology, the International Society of Nephrology, and the National Kidney Foundation. He has served on numerous Department of Medicine Committees at the University Hospitals of Cleveland, including as Chair of the Intern Selection Committee, on the Physician Practice Advisory Group, the Educational Executive Committee, and the Residency Evaluation Credentialing Committee.

    Dr. Berger graduated with a B.S. cum laude from the City University of New York, and earned his M.D. at the State University of New York, Upstate Medical Center. He completed his internship and residency at Mt. Sinai Hospital in Hartford, CT, where he served as Chief Resident. He was a Clinical Research Fellow in the Division of Nephrology at the University of California, San Francisco.

  • Catherine Meyers Broome M.D.

    Catherine Meyers Broome, M.D. is an Associate Professor of Medicine at Georgetown University in Washington DC, where she coordinates the PNH and aHUS Registries and directs the Hematology Fellowship Program. Dr. Broome has published extensively on coagulation and complement systems, is world-renowned for her expertise in the diagnosis and management of hematological rare diseases, and is an internationally recognized speaker in PNH and aHUS.

    Dr. Broome is a Diplomate of the American Board of Internal Medicine with subspecialties in Oncology and Hematology. She is a member of the American Society of Hematology, the American College of Physicians, the American Medical Association, and the American Society of Clinical Oncology.

    Dr. Broome earned her B.S. at the Louisiana State University and her M.D. at the Louisiana State University Medical School. She completed her internship and residency in Internal Medicine at the Greenville Hospital System in Greenville, S.C., where she received the Jackson Award for Outstanding Intern. Dr. Broome completed Fellowships in Hematology/Oncology at The George Washington University Hospital in Washington, DC and in Bone Marrow Transplant at the Hutchinson Cancer Center in Seattle, WA. She was a Research Fellow at the Coagulation Laboratory at The George Washington University where she received the Ross Clinician Scientist Award.

  • Kenneth V. Lieberman, M.D.

    Kenneth Lieberman M.D. is Chief of Pediatric Nephrology at The Joseph M. Sanzari Children’s Hospital at the Hackensack University Medical Center in Hackensack, NJ, and a Professor of Pediatrics at the New Jersey Medical School. Dr. Lieberman is widely recognized for his expertise in diagnosing and managing complement mediated diseases in nephrology; he has extensive clinical trial experience and patient management in aHUS, and has published numerous papers related to pediatric nephrology.

    Board Certified in Pediatrics and Pediatric Nephrology, Dr. Lieberman is a member of the International Society of Nephrology, the National Kidney Foundation, the American Society of Pediatric Nephrology, and the American Society of Transplantation among many other organizations. He also serves on numerous committees including the Kidney and Urology Foundation of America’s Council of Pediatric Nephrology and Urology, and as President of the New York Pediatric Society.

    Dr. Lieberman earned a B.S.E. in Computer Science with honors from Princeton University, Princeton, NJ and graduated with an M.D. from Albert Einstein College of Medicine, Bronx, NY. He completed his residency in Pediatrics at Mount Sinai School of Medicine, New York, NY and was a Fellow in Pediatric Nephrology at Cornell University Medical College/New York Hospital, New York. He has received many academic honors, has appeared in the Best Doctors in America database since 2000, and on New York Magazine’s “Best Doctors in New York” list since 1997.